HER2/ERBB2 copy number analysis by targeted next-generation sequencing in breast cancer
CONCLUSIONS: Copy number data from our NGS panel strongly correlate with HER2 status. Using a stringent cutoff, ERBB2 log2 ratio accurately predicts HER2 positivity with high specificity. The NGS CN assessment may have utility in determining HER2 status in certain clinical settings.PMID:38104247 | DOI:10.1093/ajcp/aqad167
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Daniel Xia Frank Kuo Melissa Hughes Neal Lindeman Danielle Manning Janet Files Sarah Strauss Greg Kirkner Ayesha Mohammed-Abreu Eric Winer Sara M Tolaney Nancy U Lin Deborah A Dillon Source Type: research