Polycomb  repressive complex 2 accessory factors: rheostats for cell fate decision?

Curr Opin Genet Dev. 2023 Dec 12;84:102137. doi: 10.1016/j.gde.2023.102137. Online ahead of print.ABSTRACTEpigenetic reprogramming during development is key to cell identity and the activities of the Polycomb repressive complexes are vital for this process. We focus on polycomb repressive complex 2 (PRC2), which catalyzes H3K27me1/2/3 and safeguards cellular integrity by ensuring proper gene repression. Notably, various accessory factors associate with PRC2, strongly influencing cell fate decisions, and their deregulation contributes to various illnesses. Yet, the exact role of these factors during development and carcinogenesis is not fully understood. Here, we present recent progress toward addressing these points and an analysis of the expression levels of PRC2 accessory factors in various tissues and developmental stages to highlight their abundance and roles. Last, we evaluate their contribution to cancer-specific phenotypes, providing insight into novel anticancer therapies.PMID:38091876 | DOI:10.1016/j.gde.2023.102137
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Source Type: research