Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury

CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC

Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research