New genes, pathways and therapeutic targets in autoinflammatory diseases

Nature Reviews Rheumatology, Published online: 14 December 2023; doi:10.1038/s41584-023-01063-8Studies in 2023 have described eight new monogenic autoinflammatory diseases and their accompanying disease-causing mutations, uncovering clinical phenotypes, pathogenic mechanisms and therapeutic targets. Researchers have identified autoinflammatory pathways linked to mitochondrial dysfunction or overactivation of SRC family kinases.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research