Safe use of contrast media in myasthenia gravis: systematic review and updated European Society of Urogenital Radiology Contrast Media Safety Committee guidelines

ConclusionsThere is limited evidence on the relationship between CM and myasthenia gravis symptoms. In the vast majority of myasthenia gravis patients, CM are safe. Probably, in less than 5% of the patients, iodine-based CM administration may lead to increased severity of the symptoms within the first 24  h after administration.Clinical relevance statementBe aware that intravenous administration of iodine-based contrast media can lead to an increase of symptoms in patients with myasthenia gravis within the first 24  h. This can probably happen in less than 5% of the patients.Key Points• It is unclear whether modern contrast media can lead to increased symptoms in myasthenia gravis patients after intravenous administration.• There seems to be a small risk of increased myasthenia gravis symptoms within 24 h after intravenous administration of iodine-based contrast media, probably in less than 5% of the administrations.• Gadolinium-based contrast media are safe for patients with myasthenia gravis.
Source: European Radiology - Category: Radiology Source Type: research