Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets

In conclusion, this study provides a molecular level explanation for the need of multiple C-P4H isoenzymes to generate collagen molecules capable to assemble into intact extracellular matrix structures.PMID:38081527 | DOI:10.1016/j.matbio.2023.12.001

Source: Matrix Biology - December 11, 2023 Category: Molecular Biology Authors: Antti M Salo Pekka Rappu M Kristian Koski Emma Karjalainen Valerio Izzi Kati Drushinin Ilkka Miinalainen Jarmo K äpylä Jyrki Heino Johanna Myllyharju Source Type: research