Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products –induced inflammation

Glucagon like peptide-1 (GLP-1) is a hormone produced and released by cells of the gastrointestinal tract following meal ingestion. GLP-1 receptor agonists (GLP-1RA) exhibit kidney-protective actions through poorly understood mechanisms. Here we interrogated whether the receptor for advanced glycation end products (RAGE) plays a role in mediating the actions of GLP-1 on inflammation and diabetic kidney disease. Mice with deletion of the GLP-1 receptor displayed an abnormal kidney phenotype that was accelerated by diabetes and improved with co-deletion of RAGE in  vivo.

Source: Kidney International - December 8, 2023 Category: Urology & Nephrology Authors: Karly C. Sourris, Yi Ding, Scott S. Maxwell, Annas Al-sharea, Phillip Kantharidis, Muthukumar Mohan, Carlos J. Rosado, Sally A. Penfold, Claus Haase, Yangsong Xu, Josephine M. Forbes, Simon Crawford, Georg Ramm, Brooke E. Harcourt, Karin Jandeleit-Dahm, A Tags: Basic Research Source Type: research