Breast cancers in monoallelic MUTYH germline mutation carriers have clinicopathological features overlapping with those in BRCA1 germline mutation carriers

ConclusionAlthough germline monoallelicMUTYH mutation is not thought to confer a meaningfully increased risk of breast cancer development, it may contribute to pathological aggressiveness and diversity of breast cancers when they sporadically arise inMUTYH carriers.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research