Nodular vasculitis (erythema induratum) associated with systemic minocycline

Australas J Dermatol. 2023 Dec 6. doi: 10.1111/ajd.14195. Online ahead of print.ABSTRACTA 29-year-old Caucasian woman presented with a 3-month history of bilateral lower limb swelling with painful erythematous nodules on shins without ulceration. She had been taking minocycline for acne vulgaris for 3 years. Biochemical investigations showed deranged liver function test with positive ANA and mixed antinuclear factor (ANF) pattern. A skin biopsy was in keeping with a diagnosis of nodular vasculitis. Her skin lesions and liver function test improved within 3 months of stopping the minocycline treatment. This case report raises the awareness that minocycline could be a potential cause of nodular vasculitis, patients on minocycline should be closely monitored and minocycline should ideally not be prescribed for more than 12 weeks, given the possible adverse effects.PMID:38057959 | DOI:10.1111/ajd.14195
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Source Type: research