Fructose sweetens the adipocyte-T cell alliance against tumors

Cell Metab. 2023 Dec 5;35(12):2093-2094. doi: 10.1016/j.cmet.2023.11.004.ABSTRACTDietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8+ T cells for improved tumor control.PMID:38056424 | DOI:10.1016/j.cmet.2023.11.004

Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Peipei Zhou Hongbo Chi Source Type: research