Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy

Semin Immunol. 2023 Nov 28;71:101848. doi: 10.1016/j.smim.2023.101848. Online ahead of print.ABSTRACTDendritic cells (DCs) are professional antigen-presenting cells that play a key role in shaping adaptive immunity. DCs have a unique ability to sample their environment, capture and process exogenous antigens into peptides that are then loaded onto major histocompatibility complex class I molecules for presentation to CD8+ T cells. This process, called cross-presentation, is essential for initiating and regulating CD8+ T cell responses against tumors and intracellular pathogens. In this review, we will discuss the role of DCs in cancer immunity, the molecular mechanisms underlying antigen cross-presentation by DCs, the immunosuppressive factors that limit the efficiency of this process in cancer, and approaches to overcome DC dysfunction and therapeutically promote antitumoral immunity.PMID:38035643 | DOI:10.1016/j.smim.2023.101848
Source: Seminars in Immunology - Category: Allergy & Immunology Authors: Source Type: research