Population PK and exposure-response (ER) analyses to support dosing of teduglutide in infant patients with short bowel syndrome (SBS)

Rationale: SBS is a malabsorption disorder resulting from a surgical resection of the bowel or a congenital condition. Patients with SBS, dependent on parenteral support (PS), may require long-term teduglutide. The PK and ER relationship in SBS infants were evaluated by a population modeling and simulation approach to support teduglutide dosing in this population.

Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: Y. Wang, J. Marier, C. Jomphe, T. Peyret, J. Victoria, S. Sabrdaran, A. Gabriel Source Type: research