IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in  acute kidney injury

Acute kidney injury (AKI) affects over 13 million people worldwide annually and is associated with a 4-fold increase in mortality. Our lab and others have shown that DNA damage response (DDR) governs the outcome of AKI in a bimodal manner. Activation of DDR sensor kinases protects against AKI, while hyperactivation of DDR effector proteins, such as p53, induces cell death and worsens AKI. The factors that trigger DDR to switch from pro-repair to pro-cell death remain to be resolved. Here we investigated the role of interleukin 22 (IL-22), an IL-10 family member whose receptor (IL-22RA1) is expressed on proximal tubule cells (PTCs), in DDR activation and AKI.

Source: Kidney International - December 4, 2023 Category: Urology & Nephrology Authors: Kensei Taguchi, Sho Sugahara, Bertha C. Elias, Navjot S. Pabla, Guillaume Canaud, Craig R. Brooks Tags: Basic Research Source Type: research