Actin' off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse

Sci Signal. 2023 Nov 28;16(813):eadl3956. doi: 10.1126/scisignal.adl3956. Epub 2023 Nov 28.ABSTRACTProgrammed cell death molecule 1 (PD-1) is a negative regulator of T cell activation; however, the mechanisms by which it acts are unclear. In this issue of Science Signaling, Paillon et al. show that PD-1 inhibits actin cytoskeletal rearrangements and associated effector responses in cytotoxic T cells.PMID:38015912 | DOI:10.1126/scisignal.adl3956
Source: Science Signaling - Category: Biomedical Science Authors: Source Type: research