Comprehensive gene profiling of the metabolic landscape of humanized livers in mice

The human liver transcriptome is complex and highly dynamic, e.g., one gene may produce multiple distinct transcripts, each with distinct posttranscriptional modifications. Direct knowledge of the transcriptome dynamics, however, is largely obscured by the inaccessibility of human liver to treatments and the insufficient annotation of the human liver transcriptome at transcript and RNA modifications levels.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research