Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells - Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts

In conclusion, MLX in combination with UVAR induces oxidative stress in melanocytes and fibroblasts, however, the analyses showed that the drug's effect the activity and expression of SOD, CAT and GPx differently, depending on the cell line. The observed dissimilarity between tested cell lines may result from the presence of melanin pigments.PMID:38036073 | DOI:10.1016/j.tiv.2023.105745

Source: Toxicology in Vitro - November 30, 2023 Category: Toxicology Authors: Marta Karkoszka Jakub Rok Justyna Kowalska Zuzanna Rzepka Klaudia Banach Dorota Wrze śniok Source Type: research