The role of ROS in tumor infiltrating immune cells and cancer immunotherapy
Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and epigenetic programs and have an indispensable role in cellular function. In immune cells, ROS are mediators of specialized functions such as phagocytosis, antigen presentation, activation, cytolysis, and differentiation. ROS have a fundamental role in the tumor microenvironment (TME) where they are produced by immune cell-intrinsic and -extrinsic mechanisms.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Rushil Shah, Betul Ibis, Monisha Kashyap, Vassiliki A. Boussiotis Tags: Review Source Type: research