Exploring Renal Function Assessment: Creatinine, Cystatin C, and Estimated Glomerular Filtration Rate Focused on the European Kidney Function Consortium Equation

Ann Lab Med. 2024 Mar 1;44(2):135-143. doi: 10.3343/alm.2023.0237. Epub 2023 Nov 1.ABSTRACTSerum creatinine and serum cystatin C are the most widely used renal biomarkers for calculating the estimated glomerular filtration rate (eGFR), which is used to estimate the severity of kidney damage. In this review, we present the basic characteristics of these biomarkers, their advantages and disadvantages, some basic history, and current laboratory measurement practices with state-of-the-art methodology. Their clinical utility is described in terms of normal reference intervals, graphically presented with age-dependent reference intervals, and their use in eGFR equations.PMID:37909162 | PMC:PMC10628758 | DOI:10.3343/alm.2023.0237
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Authors: Source Type: research