Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies

ConclusionsIn critically ill patients, total isavuconazole exposure is reduced and protein binding is highly variable. We proposed an adaptive dosing approach to enhance early treatment optimisation in this high-risk population.Clinical Trial RegistrationClinicalTrials.gov identifier: NCT04777058.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research