Cell death classification: A new insight based on molecular mechanisms

Exp Cell Res. 2023 Nov 25:113860. doi: 10.1016/j.yexcr.2023.113860. Online ahead of print.ABSTRACTCells tend to disintegrate themselves or are forced to undergo such destructive processes in critical circumstances. This complex cellular function necessitates various mechanisms and molecular pathways in order to be executed. The very nature of cell death is essentially important and vital for maintaining homeostasis, thus any type of disturbing occurrence might lead to different sorts of diseases and dysfunctions. Cell death has various modalities and yet, every now and then, a new type of this elegant procedure gets to be discovered. The diversity of cell death compels the need for a universal organizing system in order to facilitate further studies, therapeutic strategies and the invention of new methods of research. Considering all that, we attempted to review most of the known cell death mechanisms and sort them all into one arranging system that operates under a simple but subtle decision-making (If \ Else) order as a sorting algorithm, in which it decides to place and sort an input data (a type of cell death) into its proper set, then a subset and finally a group of cell death. By proposing this algorithm, the authors hope it may solve the problems regarding newer and/or undiscovered types of cell death and facilitate research and therapeutic applications of cell death.PMID:38013091 | DOI:10.1016/j.yexcr.2023.113860

Source: Experimental Cell Research - November 28, 2023 Category: Cytology Authors: Sepehr Dehghan Nasim Kheshtchin Shaghayegh Hassannezhad Maryam Soleimani Source Type: research