Minimal effective dose of bedaquiline administered orally and activity of a long acting formulation of bedaquiline in the murine model of leprosy

ConclusionWe demonstrated that the MED of BDQ administered orally againstM.leprae was 3.3 mg/kg in mice and BDQ did not add significantly to the efficacy of CFZ at the doses tested. BDQ-LA IM was similar or less active than BDQ administered orally at equivalent dosing and frequency but should be tested at higher dosing in order to reach equivalent exposure in further experiments.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research