An evaluation of Mp1p antigen screening for talaromycosis in HIV-infected antiretroviral therapy-na ïve population in Guangdong, China

by Dandan Gong, Weiyin Lin, Huihua Zhang, Xu Ou, Liya Li, Pengle Guo, Yaozu He, Cong Liu, Weiping Cai, Xiaoping Tang, Linghua Li BackgroundTalaromycosis is one of the most common opportunistic infections in human immunodeficiency virus (HIV) infected patients. However, few researches have explored the prevalence in Southern China and fully assessed the value of the Mp1p antigen screening for the diagnosis of talaromycosis. Methodology/Principal findingsWe performed a cross-sectional study of HIV-infected antiretroviral therapy (ART)-na ïve adult patients who were seen in 2018 at Guangzhou Eighth People’s Hospital, Guangzhou Medical University. Serum samples collected from all the 784 enrolled patients were tested for Mp1p antigen using double-antibody sandwich enzyme-linked immunosorbent assay. A culture of pathogen was conduct ed in 350 clinically suspected patients to confirm talaromycosis. The overall prevalence of talaromycosis based on the Mp1p antigen detection was 11.4% (89/784) and peaked at 32.2% (75/233) in patients with CD4+≤50 Nr/μl. Logistic regression analysis found Mp1p antigen positive rate decreased with the increase in CD4+ counts (OR 0.982, 95% CI 0.977 –0.987,P
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research