Exploring the mechanisms responsible for reduced systolic function in high-gradient aortic stenosis

Conclusion The pathophysiological problem in patients with high-gradient AS with rEF relates to an excessively increased afterload due to more severe valvular stenosis, with preserved intrinsic contractile function. Myocardial fibrosis in the rEF group did not translate into worse muscle function.
Source: Heart - Category: Cardiology Authors: Tags: Valvular heart disease Source Type: research