Intragastric administration of cinnamaldehyde induces changes in body temperature via TRPA1

In this study, we found that intragastric administration of cinnamaldehyde increased in the intrascapular brown adipose tissue (IBAT) and rectal temperatures. However, this effect was not observed in TRPA1 knockout mice, suggesting that TRPA1 is involved in these temperature changes. Intravenous cinnamaldehyde also increased IBAT and rectal temperatures, only in the presence of TRPA1. We also explored the contribution of the vagus nerve to these temperature changes and found that it played a limited role. These results suggest that cinnamaldehyde can affect body temperature through TRPA1 activation, with the vagus nerve having a minor influence.PMID:37994656 | DOI:10.1093/bbb/zbad163
Source: Bioscience, Biotechnology, and Biochemistry - Category: Biochemistry Authors: Source Type: research