Changes in renal blood flow (RBF) following surgically induced weight loss; can bariatric surgery halt the progression of chronic kidney disease?

In the past, we demonstrated the beneficial effects of bariatric surgery on baseline chronic kidney disease (CKD)1 –4. These findings have been supported by other observational studies, and confirmed in a recent randomized controlled trial 5–7. Nevertheless, the mechanisms behind this positive effect are yet to be elucidated to a further extent. Based on the evidence suggesting that the chronic increase in i ntra-abdominal pressure (IAP) is partial or totally responsible for an array of comorbid conditions in patients with grade III obesity, 8–10 and supported by our experience demonstrating the effects of increased IAP, intra-thoracic pressure (ITP) and intra-cranial pressure (ICP) on a non-physiolog ic release of vasopressin 11,12, we present a new hypothesis for patients with CKD and with grade III obesity.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research