Mitophagy induction improves salivary gland stem/progenitor cell function by reducing senescence after irradiation

Head and neck cancer (HNC) is the seventh most prevalent cancer worldwide [1]. The primary treatment approach for the majority of HNC patients involves radiotherapy, often in conjunction with surgery and chemotherapy [1]. Unfortunately, radiotherapy leads to a decline in a patient's quality of life, primarily due to radiation-induced damage of normal tissues [2]. Xerostomia, or dry mouth syndrome, is a side effect which results from the co-irradiation of healthy salivary glands [3]. Consequently, patients suffer from impaired speech, dental issues, and difficulties with swallowing and speaking [3].

Source: Radiotherapy and Oncology - November 23, 2023 Category: Radiology Authors: Davide Cinat, Anna Lena De Souza, Abel Soto-Gamez, Anne L. Jellema-de Bruin, Rob P. Coppes, Lara Barazzuol Tags: Original Article Source Type: research