A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease

Protein Pept Lett. 2023 Nov 16. doi: 10.2174/0109298665269246231023104904. Online ahead of print.ABSTRACTGap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous system-related diseases and treatment are reviewed.PMID:37974440 | DOI:10.2174/0109298665269246231023104904
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research