Comparison of five retinoids for anti ‐photoaging therapy: Evaluation of anti‐inflammatory and anti‐oxidative activities in vitro and therapeutic efficacy in vivo

This study aimed to determine the optimal retinoid type(s) for anti-photoaging therapy both in  vitro and in vivo. Our data demonstrated that four retinoids (RPalm, RP, HPR and ROL) but not RAc were effective for anti-photoaging treatment at 5 μg/mL in vitro, with action mechanisms associated with antioxidative, anti-inflammatory and anti-skin ECM degradation activities. Notably, both R Palm and RP appeared superior to HPR and ROL for those activities. Importantly, both RPalm and RP were shown to be optimal for anti-photoaging therapy when topically applied at 5 mg/kg in a UVB-induced mice model of photoaging, which is consistent with their high anti-photoaging activities in vit ro. Additionally, topical application of these five retinoids showed satisfactory biosafety without causing significant apoptosis in animal organs, although RP application led to a slight decline in animal body weights. Collectively, these data have laid a good foundation for the next development of the clinical application of these retinoids for skin healthcare.

Source: Photochemistry and Photobiology - November 22, 2023 Category: Science Authors: Peng Shu, Ling Jiang, Menggeng Li, Yi Li, Zhengqiang Yuan, Li Lin, Ju Wen, Haji Akber Aisa, Zhiyun Du Tags: RESEARCH ARTICLE Source Type: research