The relationship between TGF- β1 and cognitive function in the brain

Brain Res Bull. 2023 Nov 17;205:110820. doi: 10.1016/j.brainresbull.2023.110820. Online ahead of print.ABSTRACTTransforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-β1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-β1 influences cognitive function and to explore therapeutic avenues for targeting TGF-β1 in neurodegenerative conditions. This investigation sheds light on TGF-β1's contribution to cognitive function and offers prospects for innovative treatments and interventions. This review delves into the intricate relationship between TGF-β1 and cognitive function.PMID:37979810 | DOI:10.1016/j.brainresbull.2023.110820

Source: Brain Research Bulletin - November 18, 2023 Category: Neurology Authors: Chen Su Jie Miao Junhong Guo Source Type: research