How can we pharmacologically mimic the mechanisms that make gastric bypass so effective? Are we close to a “medical bypass”?

Currently, metabolic surgery (MS) constitutes the most effective means for durable weight loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non-alcoholic steatohepatitis, as well as other obesity-related comorbidities. Accumulating evidence on the mechanisms through which MS exerts its actions has highlighted the altered secretion of hormonally active peptides of intestinal origin with biological actions crucial to energy metabolism as key drivers of MS clinical effects.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research