The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B

In conclusion, our study highlights the regulated nature of p62/SQSTM1 and its ability to modulate the interaction with LC3B through a LIR-sequence Accessibility Mechanism (LAM). Furthermore, our findings suggest the potential for pharmacological modulation of the exposure of LIR, paving the way for future therapeutic strategies.This article is protected by copyright. All rights reserved.

Source: Protein Science - November 21, 2023 Category: Biochemistry Authors: Lucia Alcober ‐Boquet, Tabea Zang, Larissa Pietsch, Evelyn Suess, Markus Hartmann, Ewgenij Proschak, Lissy Z. F. Gross, Mariana Sacerdoti, Stefan Zeuzem, Vladimir V. Rogov, Alejandro E. Leroux, Albrecht Piiper, Ricardo M. Biondi Tags: RESEARCH ARTICLE Source Type: research