Advanced optical imaging for the rational design of nanomedicines

Adv Drug Deliv Rev. 2023 Nov 17:115138. doi: 10.1016/j.addr.2023.115138. Online ahead of print.ABSTRACTDespite the enormous potential of nanomedicines to shape the future of medicine, their clinical translation remains suboptimal. Translational challenges are present in every step of the development pipeline, from lack of understanding of patient heterogeneity to insufficient insights on nanoparticle properties and their impact on material-cell interactions. Here, we discuss how the adoption of advanced optical microscopy techniques, such as super-resolution optical microscopies, correlative techniques, and high-content modalities, could aid the rational design of nanocarriers, by characterizing the cell, the nanomaterial, and their interaction with unprecedent spatial and/or temporal detail. In this nanomedicine arena, we will discuss how the implementation of these techniques, with their versatility and specificity, can yield high volumes of multi-parametric data; and how machine learning can aid the rapid advances in microscopy imaging: from acquisition to data interpretation.PMID:37980951 | DOI:10.1016/j.addr.2023.115138
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Source Type: research