STATs signaling pathways in dendritic cells: As potential therapeutic targets?

Int Rev Immunol. 2023 Oct 27:1-22. doi: 10.1080/08830185.2023.2274576. Online ahead of print.ABSTRACTDendritic cells (DCs) are professional antigen-presenting cells (APCs), including heterogenous populations with phenotypic and functional diversity that coordinate bridging innate and adaptive immunity. Signal transducer and activator of transcriptions (STAT) factors as key proteins in cytokine signaling were shown to play distinct roles in the maturation and antigen presentation of DCs and play a pivotal role in modulating immune responses mediated by DCs such as differentiation of T cells to T helper (Th) 1, Th2 or regulatory T (Treg) cells. This review sheds light on the importance of STAT transcription factors' signaling pathways in different subtypes of DCs and highlights their targeting potential usages for improving DC-based immunotherapies for patients who suffer from cancer or diverse autoimmune conditions according to the type of the STAT transcription factor and its specific activating or inhibitory agent.PMID:37886903 | DOI:10.1080/08830185.2023.2274576

Source: International Reviews of Immunology - October 27, 2023 Category: Allergy & Immunology Authors: Sepideh Sohrabi Javad Masoumi Bahar Naseri Farid Ghorbaninezhad Shiva Alipour Tohid Kazemi Javad Ahmadian Heris Leili Aghebati Maleki Pedram Basirjafar Raziyeh Zandvakili Mohammad Amin Doustvandi Behzad Baradaran Source Type: research