Does baclofen for the management of spasticity increase the risk of seizures?

Scenario A 6-year-old boy with cerebral palsy (CP) (Gross Motor Function Classification System III) is attending the complex tone clinic. He was born at 28 weeks after a stormy neonatal course. He was subsequently diagnosed with periventricular leucomalacia and focal epilepsy. He is prescribed levetiracetam and has remained seizure free now for 6 months. He has increased tone (spasticity) in his lower limbs, which is impacting on activities of daily living, such as dressing. You wish to start baclofen for tone management. However, his mother is anxious as she read on a parent website that baclofen can cause seizures. Structured clinical question In children with epilepsy (patient), does baclofen (intervention) increase seizure frequency? (outcome) SearchPrimary sources MEDLINE and OVID were searched via PubMed, from 1976 to April 2023. Advanced search mode was used using the following search terms: "Baclofen" AND "seizure" OR...
Source: Archives of Disease in Childhood - Category: Pediatrics Authors: Tags: ADC Archimedes Source Type: research