Inhibition of ALA dehydratase activity in heme biosynthesis reduces cytoglobin expression which is related to the proliferation and viability of keloid fibroblasts

In conclusion, the use of succinyl acetone at a concentration of 1; 2.5; and 5 mM caused decrease ALAD enzyme activity which indicated the inhibition of the heme synthesis. Inhibition of heme synthesis can affect cytoglobin expression, which correlates with the viability and proliferation of keloid fibroblasts.PMID:37970551 | PMC:PMC10636574 | DOI:10.3164/jcbn.23-25

Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Raisa Nauli Septelia I Wanandi Mohamad Sadikin Radiana D Antarianto Sri Widia A Jusman Source Type: research