Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

Wilson et  al. show that enhanced growth rate, a hallmark of cancer, plays a key role in a cells’ sensitivity to CDK7 inhibition, by driving a permanent cell division arrest via increasing cell size beyond a point of no return. This work can guide the use of CDK inhibitors in the clinic.

Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Gemma A. Wilson, Karla Vuina, Georgina Sava, Caroline Huard, Leticia Meneguello, Jasmin Coulombe-Huntington, Thierry Bertomeu, Rory J. Maizels, Josh Lauring, Janos Kriston-Vizi, Mike Tyers, Simak Ali, Cosetta Bertoli, Robertus A.M. de Bruin Tags: Article Source Type: research