Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest

Cell growth and the cell cycle must be coordinated to preserve cell viability. Foy et  al. demonstrate that CDK4/6 inhibitors uncouple these two processes to drive excessive cellular overgrowth, DNA damage, and cell cycle exit. Oncogenic signals exacerbate these effects, likely contributing to cancer cell sensitivity to CDK4/6 inhibitors.

Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Reece Foy, Lisa Crozier, Aanchal U. Pareri, Juan Manuel Valverde, Ben Ho Park, Tony Ly, Adrian T. Saurin Tags: Article Source Type: research