Genome homeostasis defects drive enlarged cells into senescence

Manohar et  al. studied how increased cell size—a hallmark of senescence—impairs long-term proliferation. Excess cell size activates p53-p21 signaling and impairs 53BP1 recruitment to DNA double-stranded breaks. This defect correlates with an impaired DNA damage response, DNA damage sensitivity, and genom ic instability, resulting in permanent cell-cycle exit.

Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Sandhya Manohar, Marianna E. Estrada, Federico Uliana, Karla Vuina, Patricia Moyano Alvarez, Robertus A.M. de Bruin, Gabriel E. Neurohr Tags: Article Source Type: research