Transcriptional elongation control in developmental gene expression, aging, and disease
Transcriptional elongation by RNA polymerase II is a crucial regulatory step in gene expression, and its dysregulation is linked to the mechanisms underlying human disease and aging processes. This review provides a comprehensive overview of both the current mechanistic understanding and the known biological relevance of RNA Pol II elongation factors.
Source: Molecular Cell - Category: Cytology Authors: Yuki Aoi, Ali Shilatifard Tags: Review Source Type: research