Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

Pamamycins are a family of highly bioactive macrodiolide polyketides produced by Streptomyces alboniger as a complex mixture of derivatives with molecular weights ranging from 579 to 705 Daltons. The large deriva...

Source: Microbial Cell Factories - November 14, 2023 Category: Microbiology Authors: Nikolas Eckert, Yuriy Rebets, Lilya Horbal, Josef Zapp, Jennifer Herrmann, Tobias Busche, Rolf M üller, Jörn Kalinowski and Andriy Luzhetskyy Tags: Research Source Type: research