The CXCL10-CXCR3 axis plays an important role in Kawasaki Disease

Clin Exp Immunol. 2023 Nov 11:uxad125. doi: 10.1093/cei/uxad125. Online ahead of print.ABSTRACTThe precise pathogenesis of Kawasaki Disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3. Our results show that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of KD.PMID:37952216 | DOI:10.1093/cei/uxad125

Source: Clinical and Developmental Immunology - November 12, 2023 Category: Allergy & Immunology Authors: Sho Hosaka Kazuo Imagawa Yusuke Yano Lisheng Lin Junko Shiono Miho Takahashi-Igari Hideki Hara Daisuke Hayashi Hironori Imai Atsushi Morita Hiroko Fukushima Hidetoshi Takada Source Type: research