Connecting reticulophagy and neuronal NTRK2/TrkB signaling

Autophagy. 2023 Nov 8:1-2. doi: 10.1080/15548627.2023.2276630. Online ahead of print.ABSTRACTTightly regulated cell surface expression of NTRK2/TrkB provides a mechanism for fine-tuning cellular responses to the neurotrophic factor BDNF. Recently, the degradation of NTRK2 by reticulophagy has been identified as a mechanism to limit its availability for trafficking to the cell membrane. The ER-chaperone CANX (calnexin) delivers NTRK2 to the reticulophagy receptor RETREG1/Fam134b for lysosomal degradation. Upon phosphorylation of CANX, NTRK2 is released from this complex, which facilitates its cell surface transport. These results identify a novel role for CANX in regulating the cell surface expression of NTRK2 and imply a function for reticulophagy that goes beyond regulating the degradation of misfolded proteins within the ER.PMID:37941410 | DOI:10.1080/15548627.2023.2276630

Source: Autophagy - November 9, 2023 Category: Cytology Authors: Patrick L üningschrör Michael Sendtner Source Type: research