TLR2, TLR3, TLR4, TLR9 and TLR11 expression on effector CD4 < sup > + < /sup > T-cell subsets in Leishmania donovani infection

We report: CD4+t-bet+ T-cells are frequent in TLR2LowTLR3HighTLR4Low subpopulation, CD4+GATA3+ T-cells are frequent within the cells with intermediate expression of TLR2, TLR3, TLR4 and TLR11, CD4+FoxP3+ T-cells in TLR2HighTLR3High cells whereas CD4+RORγt + T-cells are frequent in TLR2LowTLR3LowTLR4LowTLR11Low cells. CD4+ effector T-cell subsets may therefore show association with TLRs- TLR3, in particular-expression. In Leishmania donovani infection in BALB/c mice, TLR3 expression on both CD4+ and CD8+ T-cells is reduced. Poly-I:C, a TLR3 ligand, do not have any distinctive effects on the CD4+ effector T-cell subsets. These data suggest that TLRs on T-cells may not function as a primary receptor that controls T-cell function but their distinctive expression profiles on different T-cell subsets suggest plausible immunomodulatory role.PMID:37949424 | DOI:10.1016/j.exppara.2023.108645

Source: Experimental Parasitology - November 10, 2023 Category: Parasitology Authors: Ashok Patidar Divanshu Shukla Neelam Bodhale Bhaskar Saha Source Type: research