Mouse TMC4 is involved in the detection of chloride taste of salts

Biosci Biotechnol Biochem. 2023 Nov 8:zbad155. doi: 10.1093/bbb/zbad155. Online ahead of print.ABSTRACTLicking behavior with various salts in Tmc4 knockout (KO) mice was observed. In Tmc4 KO mice, a significant decrease in sensitivity to chloride salts, such as NaCl, KCl, and NH4Cl, was observed, while no significant decrease in sensitivity to Na gluconate was observed. This finding suggests that TMC4 may be involved in the detection of chloride taste.PMID:37947260 | DOI:10.1093/bbb/zbad155

Source: Bioscience, Biotechnology, and Biochemistry - November 10, 2023 Category: Biochemistry Authors: Masataka Narukawa Aya Masago Momo Murata Yoshikazu Saito Yoichi Kasahara Keiko Abe Tomiko Asakura Source Type: research