Quantification of overnight urinary gonadotropin excretion predicts imminent puberty in girls: a semi-longitudinal study

CONCLUSION: FMV total U-LH and U-FSH above 0.3 IU/L and 2.5 IU/L, respectively, can be used as cut-off values to predict the manifestation of the clinical signs of puberty within 1 year. FMV total U-LH concentrations 0.3-0.8 IU/L and 0.6 IU/L may represent the range and the threshold, respectively, that reflect the loosening of the central brake on the GnRH pulse generator. An overnight increase of 20% or less in total U-LH concentrations and in the U-LH/U-FSH ratio in an early pubertal girl may serve as an indicator of imminent menarche, a presumed timing of which can be unraveled by future longitudinal studies.PMID:37934386 | DOI:10.1007/s42000-023-00499-7

Source: Hormones - November 7, 2023 Category: Endocrinology Authors: And Demir Atilla B üyükgebiz Adem Aydin Matti Hero Source Type: research