Orchid Chemicals gets USFDA nod for two generic drugs

The nod was for generic Rivastigmine capsules and Felodipine extended release tablets aimed at treating mild to moderate dementia and hypertension, respectively.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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Abstract The "biomechanical hypothesis" stipulates that with aging, the cumulative mechanical damages to the cerebral microvasculature, magnified by risk factors for vascular diseases, contribute to a breach in cerebral homeostasis producing neuronal losses. In other words, vascular dysfunction affects brain structure and function, and leads to cognitive failure. This is gathered under the term Vascular Cognitive Impairment and Dementia (VCID). One of the main culprits in the occurrence of cognitive decline could be the inevitable rise in arterial pulse pressure due to the age-dependent stiffening of lar...
Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
Clinical features related to CSF level of amyloid Aβ42 and Aβ40 proteins in presence of lobar microbleeds. Rev Neurol (Paris). 2020 Mar 14;: Authors: Girard-Stein L, Dumurgier J, Paquet C, Chabriat H Abstract In presence of lobar microbleeds, the exact clinical features related to the level of Aβ42, Aβ40 and to the Aβ40/Aβ42 ratio in the cerebrospinal fluid (CSF) are poorly known. We analyzed in 28 consecutive patients with such lesions, whose clinical or additional magnetic resonance imaging features are related to these biomarkers. The results showed that the presence of...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Unhealthy food habits are associated with non-communicable diseases (NCD) [1 –3] and nutritional deficiencies [4]. According to the World Health Organization (WHO) [5], more than half of all deaths were due to ten main causes, with the leading killers being ischaemic heart disease and stroke. Diets characterized by a low intake of fruit and vegetable (FV) and fibre increas e the risk of hypertension, diabetes mellitus (DM), obesity, cardiovascular diseases (CVD), gastrointestinal cancers, nutritional deficiencies, pancreatic diseases, depression and the development of cognitive impairment and dementia [4–7].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
This study was designed to (a) evaluate the 24-month survival rate and (b) identify the underlying cause of death in various dimensions, including cognitive, psychological, and physical function; nutritional status; and chronic disease. Methods A longitudinal study was carried out between 2011 and 2013 at seven long-term care facilities. The participants comprised 276 residents who were all older than 65 years old. Baseline measurements included cognitive function (Mini-Mental State Examination for Dementia Screening), psychological function (Cornell Scale for Depression in Dementia), physical function (Barthel Index), ...
Source: Journal of Nursing Research - Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research
This study was not perfect. You could argue, as these authors do, that the fact that participants chose their preferred diet is a good thing, as it could theoretically improve adherence. However, it also resulted in very different-sized groups to start with. The varying adherence and exercise option choices were adjusted for as well as possible. And the study relied heavily on self-reporting, which is always iffy. Healthy eating patterns have benefits beyond weight loss But we can still learn a great deal here. The Mediterranean approach to eating (which can be easily modified to suit any country or cultural food preferenc...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cooking and recipes Diet and Weight Loss Healthy Eating Source Type: blogs
Abstract BACKGROUND: In addition to the traditional risk predictors, whether anemia is an early biomarker of dementia, needs to be confirmed. OBJECTIVE: This population-based cohort study aimed to investigate the dementia risk in patients with newly diagnosed anemia using data from the Taiwan National Health Insurance Research Database. METHODS: All newly diagnosed anemia patients (n = 26,343) with no history of stroke hospitalization, central nervous disease other than dementia, psychiatric disorders, traumatic brain injury, major operations, or blood loss diseases, were enrolled. A group of non-anemic ...
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
Abstract The brain's relationship to essential hypertension is primarily understood to be that of an end-organ, damaged late in life by stroke or dementia. Emerging evidence, however, shows that heightened blood pressure (BP) early in life and prior to traditionally defined hypertension, relates to altered brain structure, cerebrovascular function, and cognitive processing. Deficits in cognitive function, cerebral blood flow (CBF) responsivity, volumes of brain areas, and white matter integrity all relate to increased but pre-hypertensive levels of BP. Such relationships may be observed as early as childhood. In t...
Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
You may have already heard the term “insulin resistance,” as it has been widely discussed by doctors and the media. But did you know that you can reduce or reverse it in the vast majority of people? Insulin resistance, i.e., the inability of the body’s cells, especially liver, muscle, and brain, to respond to insulin and allow blood sugar to enter cells, drives numerous abnormal health conditions including type 2 diabetes, hypertension, coronary heart disease, fatty liver, Alzheimer’s dementia, and cancer. It is therefore a driving force behind so many modern and common chronic health conditions. Yo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open can belly fat can insulin resistance be reversed lose weight reduce belly fat reverse inflammation visceral fat wheat belly Source Type: blogs
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Women with placental bed disorders have higher risk for vascular disease. Mechanisms behind the abnormal placentation remain elusive although maternal constitutional factors, abnormal implantation as well as impaired angiogenesis have been suggested. PMID: 32145044 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
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