Mini PROTACs: N-end rule-mediated degradation on the horizon

Trends Biochem Sci. 2023 Nov 2:S0968-0004(23)00256-6. doi: 10.1016/j.tibs.2023.10.001. Online ahead of print.ABSTRACTHeterobifunctional proteolysis-targeting chimeras (PROTACs) offer a promising cancer treatment avenue by efficiently degrading unwanted cellular proteins. A recent study from Zhang et al. demonstrated the successful utilization of the N-end rule in PROTAC design, allowing for a modular degradation rate tailored to the oncogenic driver BCR-ABL.PMID:37923612 | DOI:10.1016/j.tibs.2023.10.001
Source: Trends in Biochemical Sciences - Category: Biochemistry Authors: Source Type: research