Micro- and nanoformulations of antibiotics against Brucella

Drug Discov Today. 2023 Nov 1:103809. doi: 10.1016/j.drudis.2023.103809. Online ahead of print.ABSTRACTBrucellosis, a zoonotic intracellular bacterial infection primarily transmitted through the consumption of unpasteurized milk from infected animals, remains a challenging condition to clinically control. This is mainly because of the limited effectiveness of conventional antibiotics in targeting intracellular Brucella. Micro- and nanoformulations of antibiotics, whether used as a mono- or combination therapy, have the potential to reduce the antibiotic doses required and treatment duration. Extensive research has been conducted on various organic, semiorganic, and inorganic nanomaterials with different morphologies, such as nanoparticles (NPs), nanotubes, nanowires, and nanobelts. Metal/metal oxide, lipidic, polymeric, and carbonic NPs have been widely explored to overcome the limitations of traditional formulations. In this review, we discuss the advances and challenges of these novel formulations based on recent investigations.PMID:37923166 | DOI:10.1016/j.drudis.2023.103809
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Source Type: research