Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies
Patients with inflammatory bowel disease (IBD) have an increased risk of developing venous thromboembolic events, which have a considerable impact on morbidity and mortality. Chronic inflammation plays a crucial role in the pathogenesis of thrombotic events in patients with IBD. However, many unresolved questions remain, particularly regarding the mechanisms that determine the persistent inflammatory state independent of disease activity. This review explored the role of gut microbiota dysbiosis and intestinal barrier dysfunction, which are considered distinctive features of IBD, in determining pro-thrombotic tendencies.
Source: Thrombosis Research - Category: Hematology Authors: Alfredo Papa, Paolo Santini, Sara Sofia De Lucia, Rossella Maresca, Angelo Porfidia, Pasquale Pignatelli, Antonio Gasbarrini, Francesco Violi, Roberto Pola Source Type: research