ATAC-clock: An aging clock based on chromatin accessibility

In conclusion, we demonstrate that the clock relies on cell-intrinsic chromatin accessibility alterations rather than changes in cell composition. Further, we present a new approach to construct epigenetic aging clocks based on chromatin accessibility, which bear a direc t link to age-related transcriptional alterations, but which allow for more accurate age predictions than transcriptomic clocks.

Source: AGE - November 4, 2023 Category: Geriatrics Source Type: research